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Analysis of circadian gene expression revealed that rhythmicity of hepatic transcript levels of the majority of core clock (including Per1) and clock-regulated genes were not affected by Gα i3 deficiency. In this study, we examined the role of the GPCR (G-protein-coupled receptor)/Gα i3 (Galphai3) controlled cAMP-CREB signaling pathway in the regulation of hepatic expression of core clock and clock-regulated genes, including Dbp. However, the signaling mechanism mediating CREB-dependent regulation of DBP expression in the peripheral clock remains elusive. Gene expression of DBP itself is under the control of E-box-dependent binding by the Bmal1-Clock heterodimer and CRE-dependent binding by the cAMP responsive element binding protein (CREB). The albumin D-box binding protein (DBP) is a member of the PAR bZip (proline and acidic amino acid-rich basic leucine zipper) transcription factor family and functions as important regulator of circadian core and output gene expression.
Received: FebruAccepted: JPublished: July 13, 2018 Piekorz, email: circadian regulation galphai3/GNAI3 CREB cytochrome P450 albumin D-box binding protein Pathology Piekorz 1ġInstitut für Biochemie und Molekularbiologie II, Medizinische Fakultät der Heinrich-Heine-Universität, Düsseldorf, GermanyĢBiologisch-Medizinisches Forschungszentrum (BMFZ), Medizinische Fakultät der Heinrich-Heine-Universität, Düsseldorf, GermanyģHals-Nasen-Ohren-Klinik, Medizinische Fakultät der Heinrich-Heine-Universität, Düsseldorf, GermanyĤInstitut für Anatomie II, Medizinische Fakultät der Heinrich-Heine-Universität, Düsseldorf, GermanyĥInstitut für Klinische Chemie und Laboratoriumsmedizin, Medizinische Fakultät der Heinrich-Heine-Universität, Düsseldorf, GermanyĦIUF – Leibniz Institut für Umweltmedizinische Forschung, Düsseldorf, GermanyħKlinik für Kinderheilkunde III, Universitätsklinikum Essen, Universität Duisburg-Essen, Essen, GermanyĨCurrent address: Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
Madhurendra Singh 1, 8, Laura Bergmann 1, Alexander Lang 1, Katja Pexa 1, Fabian Kuck 1, Dennis Stibane 1, Linda Janke 5, Hakima Ezzahoini 1, Antje Lindecke 2, Constanze Wiek 3, Helmut Hanenberg 3, 7, Karl Köhrer 2, Charlotte von Gall 4, Hans Reinke 5, 6 and Roland P.